RESOLUTION OF THE CHIRAL IRON ACETYL COMPLEX [(C5H5)FE(CO)(PPH3)COCH3]

被引：15

作者：

BAKER, RW ^{[1
]}

DAVIES, SG ^{[1
]}

机构：

[1] DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(00)80348-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of the lithium enolate of racemic iron acetyl complex [(C5H5)Fe(CO)(PPh3)COCH3] with the thiolsulphonate 3, derived from homochiral (1S)-10-mercaptoisoborneol 2, provides the diastereomeric alpha-sulphides 4 and 5. Selective oxidation of diastereomer 4 to the sulphoxide 6 (k(ox.4)/k(ox.5) = ca. 20-25) allows facile separation from the sulphide 5. Subsequent desulphurisation of 6 and 5 furnishes the homochiral (R)-(-)- and (S)-(+)-acetyl complexes in overall yields (maximum 50%) of 21% and 27% respectively from the racemate.

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页码：1479 / 1480

页数：2

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