LONGITUDINAL SURVEY OF ANTICARDIOLIPIN ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS - RELATIONSHIPS WITH CLINICAL MANIFESTATIONS AND DISEASE-ACTIVITY IN AN ITALIAN SERIES

被引:18
作者
PICILLO, U
MIGLIARESI, S
MARCIALIS, MR
LONGOBARDO, A
LAPALOMBARA, F
TIRRI, G
机构
[1] Division of Rheurnatology, 1st Faculty of Medicine, Institute of Clinical Medicine, University of Naples
关键词
SYSTEMIC LUPUS ERYTHEMATOSUS; ANTIPHOSPHOLIPID; ANTICARDIOLIPIN; AUTOANTIBODIES; LONGITUDINAL SURVEY; DISEASE ACTIVITY;
D O I
10.3109/03009749209099241
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
One hundred and two patients suffering from systemic lupus erythematosus were observed over 5-140 months. IgG and IgM anticardiolipin antibodies (aCL) were searched for by ELISA in 448 serum samples, and were found in 88 (86.3%) patients on at least one occasion. Changes of aCL levels and isotypes were recorded in most patients. In patients with medium (20-80 U. GPL and/or MPL) and high (>80 U. GPL and/or MPL) aCL levels associations with thrombosis, neurological manifestations, cerebrovascular disease, prolonged aPTT, and thrombocytopenia were found. A highly significant statistical association was found between IgG aCL and the occurrence of active disease (p<0.0001).
引用
收藏
页码:271 / 276
页数:6
相关论文
共 38 条
[1]   ANTIPHOSPHOLIPID ANTIBODIES AND THE ANTIPHOSPHOLIPID SYNDROME IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A PROSPECTIVE ANALYSIS OF 500 CONSECUTIVE PATIENTS [J].
ALARCONSEGOVIA, D ;
DELEZE, M ;
ORIA, CV ;
SANCHEZGUERRERO, J ;
GOMEZPACHECO, L ;
CABIEDES, J ;
FERNANDEZ, L ;
DELEON, SP .
MEDICINE, 1989, 68 (06) :353-365
[2]  
ALARCONSEGOVIA D, 1989, J RHEUMATOL, V16, P482
[3]   THE PRIMARY ANTIPHOSPHOLIPID SYNDROME - MAJOR CLINICAL AND SEROLOGICAL FEATURES [J].
ASHERSON, RA ;
KHAMASHTA, MA ;
ORDIROS, J ;
DERKSEN, RHWM ;
MACHIN, SJ ;
BARQUINERO, J ;
OUTT, HH ;
HARRIS, EN ;
VILARDELLTORRES, M ;
HUGHES, GRV .
MEDICINE, 1989, 68 (06) :366-374
[4]   CEREBROVASCULAR-DISEASE AND ANTIPHOSPHOLIPID ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS, LUPUS-LIKE DISEASE, AND THE PRIMARY ANTIPHOSPHOLIPID SYNDROME [J].
ASHERSON, RA ;
KHAMASHTA, MA ;
GIL, A ;
VAZQUEZ, JJ ;
CHAN, O ;
BAGULEY, E ;
HUGHES, GRV .
AMERICAN JOURNAL OF MEDICINE, 1989, 86 (04) :391-399
[5]   ANTIPHOSPHOLIPID SYNDROME - 5 YEAR FOLLOW-UP [J].
ASHERSON, RA ;
BAGULEY, E ;
PAL, C ;
HUGHES, GRV .
ANNALS OF THE RHEUMATIC DISEASES, 1991, 50 (11) :805-810
[6]   RECURRENT STROKE AND MULTIINFARCT DEMENTIA IN SYSTEMIC LUPUS-ERYTHEMATOSUS - ASSOCIATION WITH ANTIPHOSPHOLIPID ANTIBODIES [J].
ASHERSON, RA ;
MERCEY, D ;
PHILLIPS, G ;
SHEEHAN, N ;
GHARAVI, AE ;
HARRIS, EN ;
HUGHES, GRV .
ANNALS OF THE RHEUMATIC DISEASES, 1987, 46 (08) :605-611
[7]   CHOREA IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND LUPUS-LIKE DISEASE - ASSOCIATION WITH ANTIPHOSPHOLIPID ANTIBODIES [J].
ASHERSON, RA ;
DERKSEN, RHWM ;
HARRIS, EN ;
BOUMA, BN ;
GHARAVI, AE ;
KATER, L ;
HUGHES, GRV .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 1987, 16 (04) :253-259
[8]   MAGNETIC-RESONANCE-IMAGING OF CENTRAL-NERVOUS-SYSTEM LESIONS IN PATIENTS WITH LUPUS-ERYTHEMATOSUS - CORRELATION WITH CLINICAL REMISSION AND ANTINEUROFILAMENT AND ANTICARDIOLIPIN ANTIBODY-TITERS [J].
BELL, CL ;
PARTINGTON, C ;
ROBBINS, M ;
GRAZIANO, F ;
TURSKI, P ;
KORNGUTH, S .
ARTHRITIS AND RHEUMATISM, 1991, 34 (04) :432-441
[9]   ISOTYPE DISTRIBUTION OF ANTICARDIOLIPIN ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS - PROSPECTIVE ANALYSIS OF A SERIES OF 100 PATIENTS [J].
CERVERA, R ;
FONT, J ;
LOPEZSOTO, A ;
CASALS, F ;
PALLARES, L ;
BOVE, A ;
INGELMO, M ;
URBANOMARQUEZ, A .
ANNALS OF THE RHEUMATIC DISEASES, 1990, 49 (02) :109-113
[10]  
COOPER RC, 1989, BRIT J RHEUMATOL, V28, P379