AN INTRACELLULAR STUDY OF THE ACTION OF NAN-190 ON NEURONS IN THE DORSAL RAPHE NUCLEUS OF THE RAT

被引：13

作者：

HODGKISS, JP

DAWSON, IM

KELLY, JS

机构：

[1] Department of Pharmacology, University of Edinburgh, Edinburgh

来源：

BRAIN RESEARCH | 1992年 / 576卷 / 01期

基金：

英国惠康基金;

关键词：

DORSAL RAPHE; SEROTONIN; INTRACELLULAR RECORDING; NAN-190; PARTIAL AGONIST; PRESYNAPTIC AUTORECEPTOR;

D O I：

10.1016/0006-8993(92)90623-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracellular recordings have been made from neurones in the dorsal raphe (DR) nucleus of the rat to determine the mechanism of action of the arylpiperazine compound NAN-190. Application of NAN-190 (50-mu-M) alone most frequently caused a hyperpolarization accompanied by a fall in R(M) and reduced the response to 5-HT and 8-OH-DPAT. After pretreatment of the preparation with the 5-HT-uptake blocker citalopram (10-mu-M) NAN-190 exerted an excitatory effect. It is concluded that NAN-190 is a partial agonist in the DR nucleus.

引用

页码：157 / 161

页数：5

共 13 条

[1] HYPERPOLARIZATION OF SEROTONERGIC NEURONS BY SEROTONIN AND LSD - STUDIES IN BRAIN-SLICES SHOWING INCREASED K+ CONDUCTANCE [J].