NEW FINDINGS AND SYMPTOMATIC TREATMENT FOR NEUROLATHYRISM, A MOTOR-NEURON DISEASE OCCURRING IN NORTH-WEST BANGLADESH

被引：16

作者：

HAQUE, A

HOSSAIN, M

KHAN, JK

KUO, YH

LAMBEIN, F

DEREUCK, J

机构：

[1] Department of Neurology, Institute of Postgraduate Medicine and Research, Dhaka

[2] Laboratory of Physiological Chemistry, University of Ghent, Gent, B-9000

[3] Department of Neurology, University of Ghent, Gent, B-9000

来源：

PARAPLEGIA | 1994年 / 32卷 / 03期

关键词：

NEUROLATHYRISM; LATHYRUS-SATIVUS; HTLV-1; OSTEOLATHYRISM; TOLPERISONE HCL; MOTOR NEURON DISEASE;

D O I：

10.1038/sc.1994.35

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neurolathyrism is a form of spastic paraparesis caused by the neuroexcitatory amino acid 3-N-oxalyl-L-2,3-diaminopropanoic acid (beta-ODAP) present in the seeds and foliage of Lathyrus sativus. The disease is irreversible and usually nonprogressive. Tolperisone HCl, a centrally acting muscle relaxant, has been shown to reduce significantly the spasticity in neurolathyrism patients. Sporadic occurrence of HTLV-1 infection (0.9%) and of osteolathyrism was found among the neurolathyrism patients. Osteolathyrism is linked to the consumption of the green shoots of Lathyrus sativus.

引用

页码：193 / 195

页数：3

共 11 条

[1]

Spencer P.S., Ludolph A., Dwivedi M.P., Roy D.N., Hugon J., Schaumburg H.H., Lathyrism: Evidence for role of the neuroexcitatory amino acid BOAA, Lancet, 2, pp. 1066-1067, (1986)

[2]

Hirano A., Liena J.F., Streifler M., Cohn D.F., Anterior horn cell changes in a case of neurolathyrism, Acta Neuropathol Neuropathol (Berlin), 35, pp. 277-283, (1976)

[3]

Lambein F., Khan J.K., Kuo Y.H., Campbell C.G., Briggs C.J., Toxins in the seedlings of some varieties of grass pea (Lathyrus sativus), Nat Toxins, 1, pp. 246-249, (1993)

[4]

Setsuo T., Toxicological studies on Mydocalm intestinal absorption and metabolic fate of Myodocalm, Pharmacology, 6, pp. 149-157, (1972)

[5]

Rudge P., Ali A., Cruickshank J.K., Multiple sclerosis, tropical spastic paraparesis and HTLV-l infection in Afro-Carribean patients in the UK, J. Neurol Neurosurg Psychiatry, 54, pp. 689-694, (1991)

[6]

Haimanot R.T., Kidane Y., Wuhib E., Kalissa A., Alemu T., Zein Z.A., Et al., Lathyrism in rural north western Ethiopia: A highly prevalent neurotoxic disorder, Intj Epidemiol, 19, pp. 664-672, (1990)

[7]

Brew B.J., Price R.W., Another retroviral disease of the nervous system. Chronic progressive myelopathy due to HTLV-1, N Englj Med, 316, pp. 1195-1197, (1988)

[8]

O'Dell B.L., Elsden D.F., Thomas J., Partridge S.M., Palmer R., Inhibition of biosynthesis of the cross-links in elastin by a lathyrogen, Nature, 209, pp. 401-402, (1966)

[9]

Cohn D.F., Streifler M., Human neurolathyrism. A follow-up study of 200 patients, Arch Suisses Neurol Neiirochir Psychiatrie, 128, pp. 151-156, (1981)

[10]

Lambein F., De Vos B., Lathyrism in young chicks induced by isoxazolin-5-one from Lathyrus odorants seedlings, Arch Lilt Physiol Biochim, 88, pp. B-66, (1981)

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