HIPPOCAMPAL DENTATE GRANULE CELL DEGENERATION AFTER ADRENALECTOMY IN THE RAT IS NOT REVERSED BY DEXAMETHASONE

被引：33

作者：

SLOVITER, RS

SOLLAS, AL

NEUBORT, S

机构：

[1] Neurology Research Center, Helen Hayes Hospital, New York State Department of Health, West Haverstraw

[2] Departments of Pharmacology and Neurology, Columbia University College of Physicians and Surgeons, New York

来源：

BRAIN RESEARCH | 1995年 / 682卷 / 1-2期

关键词：

HIPPOCAMPUS; DENTATE GYRUS; ADRENALECTOMY; CELL DEATH; APOPTOSIS; DEXAMETHASONE;

D O I：

10.1016/0006-8993(95)00350-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although adrenalectomy has been reported to induce a selective and sometimes nearly complete degeneration of hippocampal dentate granule cells, Azmitia and colleagues recently reported (Mol. Brain Res., 19 (1993) 328-332) that normal hippocampal structure can nonetheless be restored within a matter of days by dexamethasone in the drinking water. We have attempted to confirm this remarkable finding. Four months after adrenalectomy, rats were given vehicle or dexamethasone for 5 days and then sacrificed. Histological analysis revealed that vehicle-treated adrenalectomized rats exhibited a full spectrum of granule cell loss, which spanned mild to nearly complete cell loss. Dexamethasone-treated adrenalectomized rats did not differ from vehicle-treated adrenalectomized rats and, in fact, exhibited a virtually identical spectrum of granule cell loss. These results confirm that adrenalectomy reliably induces hippocampal granule cell degeneration in a majority of animals and indicate that dexamethasone does not restore normal hippocampal structure once granule cell loss has occurred.

引用

页码：227 / 230

页数：4

共 10 条

[1]

Azmitia, Liao, Dexamethasone reverses adrenalectomy-induced neuronal de-differentiation in midbrain raphe-hippocampus axis, Brain Corticosteroid Receptors, 746, pp. 180-194, (1995)

[2]

Liao, Miesak, Azmitia, Loss of 5-HT<sub>1A</sub> receptor mRNA in the dentate gyrus of the long-term adrenalectomized rats and rapid reversal by dexamethasone, Mol. Brain Res., 19, pp. 328-332, (1993)

[3]

McNeill, Masters, Finch, Effect of chronic adrenalectomy on neuron loss and distribution of sulphated glycoprotein-2 in the dentate gyrus of prepubertal rats, Exp. Neurol., 111, pp. 140-144, (1991)

[4]

Paxinos, Watson, The Rat Brain in Stereotaxic Coordinates, (1986)

[5]

Roy, Lynn, Bemm, Individual variations in hippocampal dentate degeneration following adrenalectomy, Behav. Neural Biol., 54, pp. 330-336, (1990)

[6]

Sapolsky, Stein-Behrens, Armanini, Long-term adrenalectomy causes loss of dentate gyrus and pyramidal neurons in the adult hippocampus, Exp. Neurol., 114, pp. 246-249, (1991)

[7]

Sloviter, Dean, Neubort, An electron microscopic analysis of adrenalectomy-induced hippocampal granule cell degeneration in the rat

[8]

apoptosis in the adult central nervous system, J. Comp. Neurol., 330, pp. 337-351, (1993)

[9]

Sloviter, Sollas, Dean, Neubort, Adrenalectomy-induced granule cell degeneration in the rat hippocampal dentate gyrus: characterization of an in vivo model of controlled neuronal death, J. Comp. Neurol., 330, pp. 324-336, (1993)

[10]

Sloviter, Valiquette, Abrams, Ronk, Sollas, Paul, Neubort, Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy, Science, 243, pp. 535-538, (1989)

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