ENHANCING THE YIELD AND DIASTEREOSELECTIVITY OF THE PICTET-SPENGLER REACTION - A HIGHLY EFFICIENT ROUTE TO CIS-1,3-DISUBSTITUTED TETRAHYDRO-BETA-CARBOLINES

被引：38

作者：

BAILEY, PD

MOORE, MH

MORGAN, KM

SMITH, DI

VERNON, JM

机构：

[1] STERLING WINTHROP RES CTR,STERLING WINTHROP PHARMACEUT RES DIV,DEPT CHEM DEV,ALNWICK NE66 2JH,NORTHD,ENGLAND

[2] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(00)73247-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under conditions of kinetic control, the cis-diastereoselectivity of the Pictet-Spengler reaction between tryptophan esters and aldehydes can be controlled by varying the size of the ester group; the reaction proceeds in essentially quantitative yield with most aldehydes when conducted in chloroform in the presence of molecular sieves.

引用

页码：3587 / 3588

页数：2

共 6 条

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