ABNORMAL LEVELS OF PROSTAGLANDINS AND FATTY-ACIDS IN BLOOD OF CHILDREN WITH CYSTIC-FIBROSIS

被引：106

作者：

CHASE, HP ^{[1
]}

DUPONT, J ^{[1
]}

机构：

[1] COLORADO STATE UNIV,DEPT FOOD SCI & NUTR,FT COLLINS,CO 80523

来源：

LANCET | 1978年 / 2卷 / 8083期

关键词：

D O I：

10.1016/S0140-6736(78)91746-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

12 children with cystic fibrosis (C.F.) had lower levels of the essential fatty acid, linoleic acid, in plasma and in red blood cells, than did control children, and production of prostaglandin F 2α (P.G.F2α) was higher than in controls. After 10 months of oral linoleic-acid supplementation in 6 of the children with C.F., the linoleic-acid levels in plasma, red cells, and platelets were higher and P.G.F2α production was lower than in the 6 children with C.F. who received a placebo lipid. Prostaglandin F2α is associated with bronchoconstriction and its increased production in children with C.F. might be causally related to their chronic pulmonary disease. © 1978.

引用

页码：236 / 238

页数：3

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