SURVIVAL GAIN AND VOLUME GAIN . MATHEMATICAL TOOLS IN EVALUATING TREATMENTS

被引：15

作者：

CHAHINIAN, P

ISRAEL, L

机构：

[1] Centre Hospitalier Universitaire Cochin, Paris XIVe

来源：

EUROPEAN JOURNAL OF CANCER | 1969年 / 5卷 / 06期

关键词：

D O I：

10.1016/0014-2964(69)90012-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The usual controls on the effects of chemotherapy on solid human tumors compare the evolution of tumors of different initial volumes and growth rate. They rely on the evaluation of the total survival time, in which the benefit from the treatment and the time of survival without treatment are not distinguishable. The authors propose a better quantitative appreciation by measuring the gain in survival time and in volume, which are defined in the article. These parameters are connected by simple formulae to the spontaneous doubling time and the effect of the treatment on the growth. Examples are discussed in the light of theoretical models of therapeutic response. © 1969.

引用

页码：625 / +

页数：1

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