BETA-HYDROXY-DELTA-LACTONES AS CHIRAL BUILDING-BLOCKS INVOLVING 1,3-DIHYDROXYL FUNCTIONS .1. NEW STRATEGIES FOR STEREOSELECTIVE CONSTRUCTION OF 2-METHYL-3,5-DIHYDROXY ESTERS

被引：12

作者：

FUKUI, M

OKAMOTO, S

SANO, T

NAKATA, T

OISHI, T

机构：

[1] Riken (the Institute of Physical And Chemical Research), Wako-Shi

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 10期

关键词：

5-dihydroxy ester hydroxyl-directed methylation; P-hydroxy-5-lactone P; scytophicin C roxaticin chiral building block stereoselective synthsis;

D O I：

10.1248/cpb.38.2890

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four possible isomers of 2-methyl-3,5-dihydroxy ester derivatives, useful building blocks for natural product synthesis, were synthesized stereoselectively using C3-hydroxyl-directed methylation of p-hydroxy-8-lactone and P, 5-dihydroxy ester. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2890 / 2892

页数：3

共 22 条

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