LIVER-DAMAGE, VOLUNTARY ALCOHOL INTAKE AND BRAIN HISTAMINE

被引：12

作者：

FOGEL, WA ^{[1
]}

ANDRZEJEWSKI, W ^{[1
]}

MASLINSKI, C ^{[1
]}

机构：

[1] J BRUDZINSKI MEM CITY HOSP, DEPT SURG, LODZ, POLAND

来源：

AGENTS AND ACTIONS | 1991年 / 33卷 / 1-2期

关键词：

D O I：

10.1007/BF01993152

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Liver dysfunction induced by portocaval anastomosis (PCA) in the rat is associated with a great reduction of hepatic alcohol and aldehyde dehydrogenase activities. Despite this, PCA rats voluntarily drank more alcohol than unoperated rats. When subjected to forced alcohol consumption, shunted rats maintained their exaggerated voluntary alcohol intake whereas unoperated rats developed aversion to alcohol. Hypothalamic levels of both histamine and histidine were very high in PCA rats. When these rats were chronically exposed to alcohol, there was a slight decrease in hypothalamic histidine concentration and consequently a lower histamine content. Chronic exposure to alcohol did not, however, influence hypothalamic tissue levels of histamine or histidine in unoperated rats. In both groups, chronic alcohol treatment exerted a stimulatory effect on hepatic alcohol metabolizing enzymes.

引用

页码：150 / 153

页数：4

共 9 条

[1] PATHOGENESIS OF ALCOHOL-INDUCED ACCUMULATION OF PROTEIN IN LIVER [J].