PREGNANT EPILEPTIC - REVIEW AND RECOMMENDATIONS

被引：47

作者：

MONTOURIS, GD ^{[1
]}

FENICHEL, GM ^{[1
]}

MCLAIN, LW ^{[1
]}

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT NEUROL,NASHVILLE,TN 37232

来源：

ARCHIVES OF NEUROLOGY | 1979年 / 36卷 / 10期

关键词：

D O I：

10.1001/archneur.1979.00500460035002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The major concerns in the pregnant epileptic patient are loss of seizure control and the teratogenic effects of antiepileptic drugs on the fetus. Loss of seizure control is usually caused by a progressive decline of antiepileptic plasma levels throughout pregnancy. This decline can be prevented by monthly dose adjustments based on plasma level determinations. Although infant malformations are a more prevalent outcome of the pregnancies of epileptics than of nonepileptics, the role of antiepileptic drugs in teratogenicity is not fully established. Only trimethadione has been convincingly linked to fetal malformation. Recommendations for the management of epilepsy in pregnancy are made. © 1979, American Medical Association. All rights reserved.

引用

页码：601 / 603

页数：3

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