EXPRESSION OF PERFORIN AND GRANZYMES INVIVO - POTENTIAL DIAGNOSTIC MARKERS FOR ACTIVATED CYTOTOXIC-CELLS

被引：190

作者：

GRIFFITHS, GM ^{[1
]}

MUELLER, C ^{[1
]}

机构：

[1] UNIV BERN,DEPT PATHOL,CH-3010 BERN,SWITZERLAND

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 11期

关键词：

D O I：

10.1016/0167-5699(91)90145-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Perforin and granzymes are considered to be instrumental in cell-mediated cytolysis by cytotoxic T cells and natural killer cells. Here, Gillian Griffiths and Christoph Mueller describe the expression of perforin and granzymes, emphasizing studies in vivo, and discuss the possibility that these proteins are useful diagnostic markers for immune responses involving cytolytic cells.

引用

页码：415 / 419

页数：5

共 61 条

[1] ACHAORBEA H, 1983, J IMMUNOL, V130, P2952
[2] INHIBITION OF LYMPHOCYTE MEDIATED CYTOTOXICITY BY PERFORIN ANTISENSE OLIGONUCLEOTIDES
ACHAORBEA, H
SCARPELLINO, L
HERTIG, S
DUPUIS, M
TSCHOPP, J
[J]. EMBO JOURNAL, 1990, 9 (12) : 3815 - 3819
[3] BERKE G, 1989, FUNDAMENTAL IMMUNOLO, P735
[4] BRUNET JF, 1987, J IMMUNOL, V138, P4102
[5] CHANG TW, 1980, J IMMUNOL, V124, P1028
[6] ANALYSIS OF NATURALLY-OCCURRING DELAYED-TYPE HYPERSENSITIVITY REACTIONS IN LEPROSY BY INSITU HYBRIDIZATION
COOPER, CL
MUELLER, C
SINCHAISRI, TA
PIRMEZ, C
CHAN, J
KAPLAN, G
YOUNG, SMM
WEISSMAN, IL
BLOOM, BR
REA, TH
MODLIN, RL
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (05) : 1565 - 1581
[7] HIGH-ACTIVITY OF N-ALPHA-BENZYLOXYCARBONYL-L-LYSINE THIOBENZYL ESTER SERINE ESTERASE AND CYTOLYTIC PERFORIN IN CLONED CELL-LINES IS NOT DEMONSTRABLE IN INVIVO-INDUCED CYTOTOXIC EFFECTOR-CELLS
DENNERT, G
ANDERSON, CG
PROCHAZKA, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (14) : 5004 - 5008
[8] INVIVO PRIMED MOUSE T-CELLS SELECTIVELY EXPRESS T-CELL-SPECIFIC SERINE PROTEINASE-1 AND THE PROTEINASE-LIKE MOLECULES GRANZYME-B AND GRANZYME-C
EBNET, K
CHLUBADETAPIA, J
HURTENBACH, U
KRAMER, MD
SIMON, MM
[J]. INTERNATIONAL IMMUNOLOGY, 1991, 3 (01) : 9 - 19
[9] EISENTHAL A, 1989, J IMMUNOL, V142, P2307
[10] SERINE ESTERASE AND HEMOLYTIC-ACTIVITY IN HUMAN CLONED CYTO-TOXIC LYMPHOCYTES-T
FERGUSON, WS
VERRET, CR
REILLY, EB
IANNINI, MJ
EISEN, HN
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (02) : 528 - 540

← 1 2 3 4 5 6 7 →