NEUROPSYCHIATRIC SIDE-EFFECTS AFTER THE USE OF MEFLOQUINE

被引：174

作者：

WEINKE, T

TRAUTMANN, M

HELD, T

WEBER, G

EICHENLAUB, D

FLEISCHER, K

KERN, W

POHLE, HD

机构：

[1] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW CHARLOTTENBURG,INNERE MED ABT,W-1000 BERLIN 33,GERMANY

[2] TROP MED DIENST LUFTHANSA,FRANKFURT,GERMANY

[3] KRANKENHAUS SCHWABING,MED ABT 4,MUNICH,GERMANY

[4] MISSIONSARZL KLIN,TROP MED ABT,WURZBURG,GERMANY

[5] UNIV ULM,MED KLIN & POLIKLIN,W-7900 ULM,GERMANY

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1991年 / 45卷 / 01期

关键词：

D O I：

10.4269/ajtmh.1991.45.86

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This study describes neuropsychiatric side effects in patients after treatment with mefloquine. Reactions consisted mainly of seizures, acute psychoses, anxiety neurosis, and major disturbances of sleep-wake rhythm. Side effects occurred after both therapeutic and prophylactic intake and were graded from moderate to severe. In a risk analysis of neuropsychiatric side effects in Germany, it is estimated that one of 8,000 mefloquine users suffers from such reactions. The incidence calculation revealed that one of 215 therapeutic users had reactions, compared with one of 13,000 in the prophylaxis group, making the risk of neuropsychiatric reactions after mefloquine treatment 60 times higher than after prophylaxis. Therefore, certain limitations for malaria prophylaxis and treatment with mefloquine are recommended.

引用

页码：86 / 91

页数：6

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