STRUCTURAL STUDIES ON AVIDINORUBICIN, A NOVEL ANTHRACYCLINE WITH PLATELET-AGGREGATION INHIBITORY ACTIVITY

被引：15

作者：

AOKI, M ^{[1
]}

SHIRAI, H ^{[1
]}

NAKAYAMA, N ^{[1
]}

ITEZONO, Y ^{[1
]}

MORI, M ^{[1
]}

SATOH, T ^{[1
]}

OHSHIMA, S ^{[1
]}

WATANABE, J ^{[1
]}

YOKOSE, K ^{[1
]}

SETO, H ^{[1
]}

机构：

[1] UNIV TOKYO,INST APPL MICROBIOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 06期

关键词：

D O I：

10.7164/antibiotics.44.635

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Avidinorubicin (MW 1,214, C60H86N4O22) was isolated from the cultured broth of strain NR0576 (which was identified as Streptomyces avidinii STAPLEY et al.) by butyl alcohol extraction, Sephadex LH-20 column chromatography and preparative HPLC. Avidinorubicin inhibited thrombin-induced platelet aggregation with an IC50 being 7.9-mu-M and was determined to be a novel anthracycline possessing two units of a new aminosugar, avidinosamine, in place of two decilonitrose groups in decilorubicin.

引用

页码：635 / 645

页数：11

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