INTRATHECAL MIDAZOLAM VERSUS INTRATHECAL MORPHINE IN OROFACIAL NOCICEPTION - AN EXPERIMENTAL-STUDY IN RATS

被引：13

作者：

AIGOUY, L

FONDRAS, JC

PAJOT, J

SCHOEFFLER, P

WODA, A

机构：

[1] UER ODONTOL, PHYSIOL OROFACIALE LAB, CLERMONT FERRAND, FRANCE

[2] CHU CLERMONT FERRAND, DEPT ANESTHESIE REANIMAT, F-63003 CLERMONT FERRAND, FRANCE

来源：

NEUROSCIENCE LETTERS | 1992年 / 139卷 / 01期

关键词：

BENZODIAZEPINE ANTINOCICEPTION; MIDAZOLAM; INTRATHECAL INJECTION; INTRATHECAL MIDAZOLAM; MORPHINE; RAT; FORMALIN TEST;

D O I：

10.1016/0304-3940(92)90866-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The antinociceptive properties of intrathecal midazolam (15 and 30-mu-g) and intrathecal morphine (30-mu-g) were compared using an adaptation of the formalin test to the orofacial region in rats. Both midazolam and morphine were effective in reducing the nociceptive response of the second phase of this biphasic pain test. Only midazolam (30-mu-g) reduced also the first phase. These results confirm the existence of analgesic properties of midazolam in the case of long-lasting pain.

引用

页码：97 / 99

页数：3

共 20 条

[1] MORPHINE ANALGESIA IN THE TAIL-FLICK AND FORMALIN PAIN TESTS IS MEDIATED BY DIFFERENT NEURAL SYSTEMS [J].