NEW EVIDENCE FOR THE INSERTION OF MITOCHONDRIAL-DNA INTO THE HUMAN GENOME - SIGNIFICANCE FOR CANCER AND AGING

被引:78
作者
SHAY, JW
WERBIN, H
机构
[1] The University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology and Neuroscience, Dallas
来源
MUTATION RESEARCH | 1992年 / 275卷 / 3-6期
关键词
MOBILE MITOCHONDRIAL DNA; INSERTIONS; TRANSPOSITIONS; CANCER; AGING;
D O I
10.1016/0921-8734(92)90026-L
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We have observed and characterized in detail two cases of mitochondrial DNA fragments which have inserted into the nucleus of HeLa cells. In one case three non-sequential but contiguous regions of mitochondrial DNA with 92% homology to human cytoplasmic mitochondrial DNA inserted into the nuclear genome. In the second case the mitochondrial DNA sequence encoding cytochrome c oxidase subunit III was contiguous with and 5' of exons 2 and 3 of the c-myc oncogene and the chimeric gene was transcribed. Models are presented that describe mechanisms for the transfer of mitochondrial DNA into the nucleus involving fragmentation of mitochondrial DNA through aging and/or oxidative damage, anomalous processing or escape of mitochondrial DNA and RNA fragments from autophagic vacuoles, and insertion of mitochondrial DNA sequences, in some instances after reverse transcription of mitochondrial RNA, into the nuclear genome.
引用
收藏
页码:227 / 235
页数:9
相关论文
共 52 条
[1]   MITOCHONDRIAL MUTATIONS MAY INCREASE OXIDATIVE STRESS - IMPLICATIONS FOR CARCINOGENESIS AND AGING [J].
BANDY, B ;
DAVISON, AJ .
FREE RADICAL BIOLOGY AND MEDICINE, 1990, 8 (06) :523-539
[2]   A NUCLEUS WITH CYTOPLASMIC FEATURES [J].
BLOOM, GD .
JOURNAL OF CELL BIOLOGY, 1967, 35 (01) :266-&
[3]   NUCLEAR MITOCHONDRIA [J].
BRANDES, D ;
SCHOFIEL.BH ;
ANTON, E .
SCIENCE, 1965, 149 (3690) :1373-&
[4]   REPLICATION AND TRANSCRIPTION OF VERTEBRATE MITOCHONDRIAL-DNA [J].
CLAYTON, DA .
ANNUAL REVIEW OF CELL BIOLOGY, 1991, 7 :453-478
[5]  
COLLINS VP, 1980, LAB INVEST, V42, P209
[6]   DNA-SEQUENCES HOMOLOGOUS TO MITOCHONDRIAL GENES IN NUCLEI FROM NORMAL RAT-TISSUES AND FROM RAT HEPATOMA-CELLS [J].
CORRAL, M ;
BAFFET, G ;
KITZIS, A ;
PARIS, B ;
TICHONICKY, L ;
KRUH, J ;
GUGUENGUILLOUZO, C ;
DEFER, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 162 (01) :258-264
[7]   RNAS CONTAINING MITOCHONDRIAL ND6 AND COI SEQUENCES PRESENT AN ABNORMAL STRUCTURE IN CHEMICALLY-INDUCED RAT HEPATOMAS [J].
CORRAL, M ;
KITZIS, A ;
BAFFET, G ;
PARIS, B ;
TICHONICKY, L ;
KRUH, J ;
GUGUENGUILLOUZO, C ;
DEFER, N .
NUCLEIC ACIDS RESEARCH, 1989, 17 (13) :5191-5206
[8]  
CORTOPASSI GA, 1990, NUCLECI ACIDS RES, V18, P6929
[9]   DIFFERENT MECHANISMS INFERRED FROM SEQUENCES OF HUMAN MITOCHONDRIAL-DNA DELETIONS IN OCULAR MYOPATHIES [J].
DEGOUL, F ;
NELSON, I ;
AMSELEM, S ;
ROMERO, N ;
OBERMAIERKUSSER, B ;
PONSOT, G ;
MARSAC, C ;
LESTIENNE, P .
NUCLEIC ACIDS RESEARCH, 1991, 19 (03) :493-496
[10]  
DEOMBROSKI BA, 1991, SCIENC E, V254, P1805