GELSOLIN IS LOCALIZED IN NEURONAL GROWTH CONES

被引：48

作者：

TANAKA, J ^{[1
]}

KIRA, M ^{[1
]}

SOBUE, K ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT NEUROCHEM & NEUROPHARMACOL,BIOMED RES CTR,SUITA,OSAKA 565,JAPAN

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1993年 / 76卷 / 02期

关键词：

GELSOLIN; ACTIN; GROWTH CONE; CA2+; CELL MOTILITY; PC12; CELL; NEURON;

D O I：

10.1016/0165-3806(93)90217-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gelsolin, a Ca2+-sensitive actin filament-severing protein, is involved in actin turnover. Immunocytochemical study with anti-gelsolin antibody revealed that the protein is localized in both filopodia and the body part of growth cones of differentiated PC12 cells with nerve growth factor (NGF) and of rat dorsal root ganglion neurons. Here, we identified gelsolin as one of the molecular bases for the Ca2+-dependent movement of growth cones.

引用

页码：268 / 271

页数：4

共 10 条

[1]

Bamburg J. R., 1991, NEURONAL CYTOSKELETO, P121

[2] PURIFICATION AND CULTURE OF ADULT-RAT DORSAL-ROOT GANGLIA NEURONS [J].