Negative priming (NP) is commonly thought to occur because distractor inhibition is necessary for target selection (the distractor inhibition hypothesis). Contrary to this account, the selection of a target in the preceding trial is shown to be neither necessary (Experiment 1) nor sufficient (Experiments 2 and 3) for NP in a target localization task modeled after S. P. Tipper, J. C. Brehaut, and J. Driver (1990). Experiments 4 and 5 provide further evidence against the distractor inhibition hypothesis and support an alternative mismatching account: NP in the spatial selection task apparently results from a change in the symbol bound to a given location (D. Kahneman, A. M. Treisman, & B. J. Gibbs, 1992), rather than a change in the status of that location from distractor to target (S. P. Tipper, J. C. Brehaut, & J. Driver, 1990).