RAD58 (XRS4) - A NEW GENE IN THE RAD52 EPISTASIS GROUP

被引：17

作者：

CHEPURNAYA, OV ^{[1
]}

KOZHIN, SA ^{[1
]}

PESHEKHONOV, VT ^{[1
]}

KOROLEV, VG ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,PETERSBURG NUCL PHYS INST,DEPT MOLEC & RADIAT BIOPHYS,GENET EUKARYOTES LAB,GATCHINA 188350,RUSSIA

来源：

CURRENT GENETICS | 1995年 / 28卷 / 03期

关键词：

YEAST; RAD58; REPAIR; RECOMBINATION;

D O I：

10.1007/BF00309787

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The RAD58 (XRS4) gene of Saccharomyces cerevisiae has been previously identified as a DNA repair gene. In this communication, we show that RAD58 also encodes an essential meiotic function. The spore inviability of rad58 strains is not rescued by a spo13 mutation. The rad50 mutation suppresses spore inviability of a spo13 rad58 strain suggesting that RAD58 acts after RAD50 in meiotic recombination. The rad58-4 mutation does not prevent mitotic recombination events. Haploid rad58 cells fail to carry out G(2)-repair of gamma-induced lesions, whereas rad58/rad58 diploids are able to perform some diploid-specific repair of these lesions.

引用

页码：274 / 279

页数：6

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