MAGNETIC-RESONANCE-IMAGING OF EXPERIMENTAL RAT-BRAIN TUMORS - HISTOPATHOLOGICAL EVALUATION

被引：13

作者：

BABA, T

MORIGUCHI, M

NATORI, Y

KATSUKI, C

INOUE, T

FUKUI, M

机构：

[1] KATSUKI NEUROSURG CLIN,FUKUOKA,JAPAN

[2] KYUSHU UNIV,INST NEUROL,DEPT NEUROSURG,FUKUOKA 812,JAPAN

来源：

SURGICAL NEUROLOGY | 1990年 / 34卷 / 06期

关键词：

Blood-brain barrier; Evans blue; Gadolinium-diethylenetriaminepentaacetic acid; Magnetic resonance imaging; Rat; RG-C6; glioma;

D O I：

10.1016/0090-3019(90)90240-P

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using RG-C6 glioma-transplanted rats, we studied precontrast and postcontrast magnetic resonance imaging, extravasation of Evans blue, and histology. In all rats, tumor was enhanced with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA). The necrotic portion in the tumor, however, was not enhanced. Hemorrhage and hydrocephalus were clearly visualized on both the precontrast and postcontrast images. Blood-brain barrier-disrupted areas stained with Evans blue and areas enhanced with Gd-DTPA on magnetic resonance imaging were nearly consistent. It is suggested that the mechanism of brain tumor enhancement with Gd-DTPA on magnetic resonance imaging is simply related to the degree of alteration of the blood-brain barrier. The Gd-DTPA-enhanced magnetic resonance imaging, even with low magnetic field, is useful for the evaluation of size, shape, and location of experimental rat brain tumors. © 1990.

引用

页码：378 / 382

页数：5

共 8 条

[1] MORPHOLOGICAL AND IMMUNOCHEMICAL STUDIES OF RAT GLIAL TUMORS AND CLONAL STRAINS PROPAGATED IN CULTURE [J].