INHIBITORY-ACTION OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) IN THE MOUSE COLON

被引：4

作者：

CADIEUX, A ^{[1
]}

POMERLEAU, F ^{[1
]}

STPIERRE, S ^{[1
]}

FOURNIER, A ^{[1
]}

机构：

[1] UNIV QUEBEC,INST NATL RECH SCI SANTE,MONTREAL H1N 3M5,QUEBEC,CANADA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb06612.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— The effect and mechanism of action of calcitonin gene‐ related peptide (CGRP) have been investigated on the mouse distal colon. CGRP caused a concentration‐dependent relaxation which was not blocked by classical pharmacological antagonists. The response pattern was characterized by a relatively rapid onset and long sustained duration. The results suggest that CGRP itself may contribute to regulating the muscular tone of the mouse colon. 1990 Royal Pharmaceutical Society of Great Britain

引用

页码：520 / 521

页数：2

共 16 条

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