PREPARATION OF OPTICALLY-ACTIVE ALPHA-HYDROXY KETONE DERIVATIVES BY ENZYME-MEDIATED HYDROLYSIS OF ENOL ESTERS

被引：9

作者：

MATSUMOTO, K ^{[1
]}

SUZUKI, N ^{[1
]}

OHTA, H ^{[1
]}

机构：

[1] KEIO UNIV,DEPT CHEM,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(00)97267-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method of preparation of optically active α-hydroxy ketone derivatives has been developed. Incubation of (Z)-3-propionyloxy-4-benzyloxy-2-pentene (1a) with lipase OF gave optically pure (R)-enol propionate 1a, which in turn was convened without racemization to (R)-ketone 2a by the aid of LiAlH4. © 1990.

引用

页码：7159 / 7162

页数：4

共 4 条

[1] QUANTITATIVE-ANALYSES OF BIOCHEMICAL KINETIC RESOLUTIONS OF ENANTIOMERS [J].