HEAT-SHOCK RESPONSE OF SPIROCHETES

被引：64

作者：

STAMM, LV ^{[1
]}

GHERARDINI, FC ^{[1
]}

PARRISH, EA ^{[1
]}

MOOMAW, CR ^{[1
]}

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC 27599

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 04期

关键词：

D O I：

10.1128/IAI.59.4.1572-1575.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the heat shock response of the pathogenic spirochets Treponema pallidum, Borrelia burgdorferi, and Leptospira interrogans and certain saprophytic spirochetes. Cellular proteins synthesized after shifts to higher temperatures were [S-35]methionine labeled and analyzed by gel electrophoresis and fluorography. Only T. pallidum failed to exhibit an obvious heat shock response. GroEL and DnaK homologs were identified in the various species, although these proteins were not thermoinducible in T. pallidum or Treponema denticola. DNA hybridization studies indicate that spirochetal groEL and dnaK genes are highly conserved.

引用

页码：1572 / 1575

页数：4

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