CRYSTAL-INDUCED NEUTROPHIL ACTIVATION .1. INITIATION AND MODULATION OF CALCIUM MOBILIZATION AND SUPEROXIDE PRODUCTION BY MICROCRYSTALS

被引：56

作者：

NACCACHE, PH

GRIMARD, M

ROBERGE, CJ

GILBERT, C

LUSSIER, A

DEMEDICIS, R

POUBELLE, PE

机构：

[1] UNIV LAVAL,DEPT MED,UNITE RECH INFLAMMAT & IMMUNOL RHUMATOL,QUEBEC CITY G1K 7P4,QUEBEC,CANADA

[2] CHU SHERBROOKE,UNITE MALAD RHUMATISMALES,SHERBROOKE J1H 5N4,QUEBEC,CANADA

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 03期

关键词：

D O I：

10.1002/art.1780340311

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of monosodium urate and calcium pyrophosphate dihydrate crystals on the levels of cytoplasmic free calcium and on the oxidative burst in normal human blood neutrophils were examined. The pattern of sensitivity to granulocyte-macrophage colony-stimulating factor, colchicine, cytochalasin B, pertussis toxin, diglyceride kinase, and protein kinase C inhibitors differentiated the mechanism(s) of neutrophil activation by the crystals from that involved in the responses to soluble chemotactic factors and indicated that individual crystals can use several activation pathways.

引用

页码：333 / 342

页数：10

共 57 条

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