LOCALIZATION OF XANTHINE-OXIDASE TO SYNOVIAL ENDOTHELIUM

被引：37

作者：

STEVENS, CR

BENBOUBETRA, M

HARRISON, R

SAHINOGLU, T

SMITH, EC

BLAKE, DR

机构：

[1] UNIV LONDON LONDON HOSP,COLL MED,LONDON INFLAMMAT GRP,ARC BONE & JOINT RES UNIT,LONDON E1 2AD,ENGLAND

[2] UNIV BATH,DEPT BIOCHEM,BATH BA2 7AY,AVON,ENGLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1991年 / 50卷 / 11期

关键词：

D O I：

10.1136/ard.50.11.760

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The presence of the xanthine oxidase enzyme system has been demonstrated in the rheumatoid synovium. This supplies a reactive oxygen species generating system to synovium that is subjected to hypoxic-reperfusion cycles (cf inflamed rheumatoid synovium). An antibody to bovine milk xanthine oxidase has been used to localise the enzyme by immunohistochemistry to synovial endothelium. This implicates the endothelial cell as playing a major part in exacerbations of synovitis, induced by radicals.

引用

页码：760 / 762

页数：3

共 13 条

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