BIOASSAY OF INTERLEUKIN-1 (IL-1) IN HUMAN GINGIVAL CREVICULAR FLUID DURING EXPERIMENTAL GINGIVITIS

被引：75

作者：

KINANE, DF ^{[1
]}

WINSTANLEY, FP ^{[1
]}

ADONOGIANAKI, E ^{[1
]}

MOUGHAL, NA ^{[1
]}

机构：

[1] GLASGOW ROYAL INFIRM,DEPT PATHOL BIOCHEM,GLASGOW G4 0SF,SCOTLAND

来源：

ARCHIVES OF ORAL BIOLOGY | 1992年 / 37卷 / 02期

关键词：

INTERLEUKIN-1; EXPERIMENTAL GINGIVITIS;

D O I：

10.1016/0003-9969(92)90011-V

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The cytokine IL-1 was demonstrated in crevicular fluid during a 14- and 21-day experimental gingivitis in healthy human volunteers. A sensitive and specific bioassay allowed detection of biologically active IL-1 at levels ranging from 0.18 ng/mu-l at baseline to 1.70 ng/mu-l in inflamed gingiva. Levels of IL-1 increased rapidly with plaque accumulation and in advance of the subsequent gingival inflammation, peaking within 7 days of the start of gingivitis. As changes in IL-1 were detected before clinically recognizable gingival changes, IL-1 may have potential as an early marker of gingival inflammatory changes.

引用

页码：153 / 156

页数：4

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