IMMORTALIZATION OF HUMAN T-CELLS BY HERPESVIRUS-SAIMIRI

被引：78

作者：

MEINL, E

HOHLFELD, R

WEKERLE, H

FLECKENSTEIN, B

机构：

[1] MAX PLANCK INST PSYCHIAT,DEPT NEUROIMMUNOL,D-82152 MARTINSRIED,GERMANY

[2] UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEUROL,D-81366 MUNICH,GERMANY

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 02期

关键词：

D O I：

10.1016/0167-5699(95)80087-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The limited growth capacity of human T cells in vitro has been a barrier to studies of essential functions. Recent work shows that Herpesvirus saimiri, a lymphotropic agent of nonhuman primates, can immortalize human T cells such that they become independent of antigen and accessory cells. Edgar Meinl and colleagues suggest that, similar to EBV-transformation of B cells, this will be a powerful tool for studies of T-cell physiology.

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页码：55 / 58

页数：4

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