PATIENTS WITH ENTERIC ADENOVIRUS GASTROENTERITIS ADMITTED TO AN AUSTRALIAN PEDIATRIC TEACHING HOSPITAL FROM 1981 TO 1992

During the period 1981 to 1999, 4,473 fecal specimens collected from children hospitalized with acute gastroenteritis at the Royal Children's Hospital, Melbourne, Australia, were examined by electron microscopy, A monoclonal antibody enzyme immunoassay for enteric adenovirus (EAd) types 40 (Ad40) and 41 (Ad41) was used when adenoviruses were visualized, Fecal samples were positive for adenovirus by both electron microscopy and enzyme immunoassay in 138 patients (3.1%), Ad40 was identified in 19 children (14%), and Ad41 was identified in 119 children (86%), These EAd were identified during each of the 12 years surveyed, EAd were present year-round, but the annual number of hospitalizations was not constant. Yearly prevalence varied from 0.7% (1981) to 6.5% (1985), This was associated with monthly fluctuations in Ad41 activity, with overall peak monthly prevalence in May (late autumn), By contrast, Ad40 numbers remained low and constant year-round. The frequency of Ad41 relative to Ad40 increased from 25% in 1981 to exceed 75% after 1983. Children admitted,vith EAd infection were more likely to have diarrhea for more than 5 days (P < 0.001) but less likely to be febrile or dehydrated (P < 0.05) than children with rotavirus infection, EAd are responsible for enteric symptoms of only a fraction of hospitalized children with infectious diarrhea but result in a more-protracted illness than rotavirus, Their relationship to persistent diarrhea requires further investigation.