ABSORPTION OF CHLORHEXIDINE FROM THE INTACT SKIN OF NEWBORN-INFANTS

被引：70

作者：

COWEN, J

ELLIS, SH

MCAINSH, J

机构：

[1] HAMMERSMITH HOSP,DEPT NEONATAL MED,LONDON W12 0HS,ENGLAND

[2] HAMMERSMITH HOSP,DEPT PAEDIAT,LONDON W12 0HS,ENGLAND

[3] ICI LTD,DIV PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1979年 / 54卷 / 05期

关键词：

D O I：

10.1136/adc.54.5.379

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

34 newborn infants who had been bathed in a standard manner with Hibiscrub, a detergent-based preparation containing 4% Hibitane chlorhexidine gluconate, were studied to find out whether it was absorbed percutaneously. Low levels of chlorhexidine were found in the blood of all 10 newborns sampled by heel prick, and 5 of 24 from whom venous blood was taken. The detection of chlorhexidine varied greatly with the method and timing of sampling, and no correlation was found between gestational or postnatal age and chlorhexidine levels.

引用

页码：379 / 383

页数：5

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