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INVOLVEMENT OF SUPEROXIDE IN THE PARAQUAT-INDUCED ENHANCEMENT OF LUNG COLLAGEN-SYNTHESIS IN ORGAN-CULTURE

被引：22
作者：
HUSSAIN, MZ
BHATNAGAR, RS
机构：
[1] Laboratory of Connective Tissue Biochemistry School, Dentistry University of California, San Francisco
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 01期
关键词：
D O I：
10.1016/0006-291X(79)90944-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Exposure to paraquat in vivo results in increased synthesis and deposition of collagen. We examined collagen synthesis in organ cultures of neo-natal rat lungs in the presence of paraquat. Paraquat markedly increased the synthesis and accumulation of collagen in these cultures. This effect was abolished by superoxide dismutase. Our studies suggest that the mechanism of paraquat mediated increase in collagen synthesis may involve superoxide. © 1979.
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页码：71 / 76
页数：6
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