PROTOONCOGENE EXPRESSION IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS IN IGA NEPHROPATHY

被引：19

作者：

EBIHARA, I ^{[1
]}

NAKAMURA, T ^{[1
]}

SUZUKI, S ^{[1
]}

TOMINO, Y ^{[1
]}

KOIDE, H ^{[1
]}

机构：

[1] JUNTENDO UNIV,SCH MED,DEPT MED,DIV NEPHROL,TOKYO 113,JAPAN

来源：

KIDNEY INTERNATIONAL | 1991年 / 39卷 / 05期

关键词：

D O I：

10.1038/ki.1991.119

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We have investigated the expression of proto-oncogenes in mononuclear cells obtained from patients with IgA nephropathy using a RNA hybridization technique. Patients with IgA nephropathy expressed more c-myc, c-raf, c-fos, and c-jun proto-oncogene RNA than did normal controls. However, no significant expression of c-N-ras, c-mos or c-myb genes was found in the mononuclear cells of these patients. When the amount of urinary protein excretion was used as an indicator of disease activity (> 1 g/day), a positive correlation was found between c-myc, c-raf, c-fos, and c-jun expression and urinary protein excretion (P < 0.01). The expression of these genes correlated also with the serum IgA concentration (P < 0.01), IgA immune complex (P < 0.01), and histopathological changes in renal tissues obtained from patients with IgA nephropathy (P < 0.01). The results of this survey suggest that abnormally regulated proto-oncogene expression in mononuclear cells may play an important role in the progression of IgA nephropathy and may be useful as an indicator of disease activity and/or prognosis.

引用

页码：946 / 953

页数：8

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