BRADYCARDIAC RESPONSES ELICITED BY ALCOHOL ODOR IN RAT NEONATES - INFLUENCE OF INUTERO EXPERIENCE WITH ETHANOL

被引：34

作者：

CHOTRO, MG ^{[1
]}

MOLINA, JC ^{[1
]}

机构：

[1] INST INVEST MED M&M FERREYRA, CASILLA CORREO 389, RA-5000 CORDOBA, ARGENTINA

来源：

PSYCHOPHARMACOLOGY | 1992年 / 106卷 / 04期

关键词：

ALCOHOL; RAT FETUSES; AMNIOTIC FLUID; NOCICEPTIVE STIMULATION; HEART RATE; PRENATAL LEARNING;

D O I：

10.1007/BF02244820

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two experiments were performed in order to assess neonatal responsiveness to alcohol odor as a function of prior acute in utero experience with this drug. In experiment 1 the amniotic fluid surrounding rat fetuses of 21 days of gestation was either contaminated with alcohol or lemon solutions or with physiological saline. Neonatal presentation of alcohol odor induced stable and relatively low cardiac decelerations in saline and lemon exposed rats. Alcohol prenatal administration resulted in stronger bradycardiac patterns that lasted throughout most of the testing procedure. In experiment 2 these results were replicated and it was observed that nociceptive stimulation paired with alcohol prenatal administration significantly inhibited neonatal responsiveness to ethanol odor. The results indicate that learning relative to alcohol derived cues is likely to occur in utero. Furthermore, expression of acquisition is detected almost immediately after birth when employing an autonomic index frequently related with orienting responses to relevant stimuli.

引用

页码：491 / 496

页数：6

共 36 条

[1]

Abel E. L., 1984, FETAL ALCOHOL SYNDRO

[2]

BRUNJES P, 1979, COMP PHYSL PSYCHOL, V93, P548

[3] SHORT-TERM EXPOSURE TO AN ODOR INCREASES ITS SUBSEQUENT PREFERENCE IN PREWEANLING RATS - A DESCRIPTIVE PROFILE OF THE PHENOMENON [J].

CAZA, PA ;

SPEAR, NE .

DEVELOPMENTAL PSYCHOBIOLOGY, 1984, 17 (04) :407-422

[4] THE INTRAUTERINE HEARTBEAT - A POTENT REINFORCER FOR NEWBORNS [J].

DECASPER, AJ ;

SIGAFOOS, AD .

INFANT BEHAVIOR & DEVELOPMENT, 1983, 6 (01) :19-25

[5]

EMORY EK, 1988, BEHAVIOR FETUS, P141

[6]

Fifer W.P., 1988, BEHAVIOR FETUS, P175

[7] AVERSION LEARNING IN 5-DAY-OLD RATS - TASTE-TOXICOSIS AND TEXTURE-SHOCK ASSOCIATIONS [J].

GEMBERLING, GA ;

DOMJAN, M ;

AMSEL, A .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1980, 94 (04) :734-745

[8] SELECTIVE ASSOCIATIONS IN ONE-DAY-OLD RATS - TASTE-TOXICOSIS AND TEXTURE-SHOCK AVERSION LEARNING [J].

GEMBERLING, GA ;

DOMJAN, M .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1982, 96 (01) :105-113

[9] EMERGENCE OF INTEROCEPTIVE AND EXTEROCEPTIVE CONTROL OF BEHAVIOR IN RATS [J].

HAROUTUNIAN, V ;

CAMPBELL, BA .

SCIENCE, 1979, 205 (4409) :927-929

[10]

IMAZ FAU, 1983, OBSTETRICIA PRACTICA

← 1 2 3 4 →