ANTINOCICEPTIVE MECHANISM OF THE ACONITINE ALKALOIDS MESACONITINE AND BENZOYLMESACONINE

被引：69

作者：

SUZUKI, Y ^{[1
]}

OYAMA, T ^{[1
]}

ISHIGE, A ^{[1
]}

ISONO, T ^{[1
]}

ASAMI, A ^{[1
]}

IKEDA, Y ^{[1
]}

NOGUCHI, M ^{[1
]}

OMIYA, Y ^{[1
]}

机构：

[1] TSUMURA & CO,TSUMURA CENT RES LABS,AMI,IBARAKI 30011,JAPAN

来源：

PLANTA MEDICA | 1994年 / 60卷 / 05期

关键词：

MESACONITINE; BENZOYLMESACONINE; ACONITUM CARMICHAELI; RANUNCULACEAE; ANALGESIA; BRAIN STEM;

D O I：

10.1055/s-2006-959516

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We explored the possible role of the specific regions in the brain stem on the antinociceptive actions of mesaconitine (MA) and benzoylmesaconine (BM) by the microinjection of MA and BM into nucleus reticularis paragigantocellularis (NRPG), nucleus raphe magnus (NRM), and periaqueductal gray (PAG). MA microinjected into NRPG, NRM, or FAG elicited a dose-dependent antinociceptive action, whereas BM injected into NRM or FAG elicited a dose-dependent antinociceptive action but not in NRPG. The NRM appeared to be the most sensitive region among the three tested locations.

引用

页码：391 / 394

页数：4

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