PROSTAGLANDIN RELEASE FROM LUMBAR DISC AND FACET JOINT TISSUE

被引：48

作者：

WILLBURGER, RE

WITTENBERG, RH

机构：

[1] Department of Orthopaedic Surgery, Ruhr University, Bochum

来源：

SPINE | 1994年 / 19卷 / 18期

关键词：

DISC; FACET JOINTS; PROSTAGLANDINS; LEUKOTRIENES; INFLAMMATION;

D O I：

10.1097/00007632-199409150-00011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives. The authors measured prostaglandin (PG) and leukotriene (LT) release from human disc and lumbar facet joint tissues. Summary of Background Data. High levels of phospholipase A2 (PLA2) have been measured in the human disc. PLA2 releases fatty acids from lipid membranes. These can be converted to PG and LT, which are potent inflammatory mediators and supposed to be involved in lumbar diseases. Methods. The tissues were obtained during surgery and incubated in Tyrode's solution. PG and LT release was measured radioimmunologically from the supernatant. Results. Disc (4 ng/g wet weight), cartilage (21 ng/g wet weight), and bone (14 ng/g wet weight) released PGs but no LTs. Conclusion. Because PG release from sequestrated disc is rather low, the inflammatory effect might be more because of immunologic reactions.

引用

页码：2068 / 2070

页数：3

共 24 条

[1]

Aehringhaus U., Wolbing R.H., Konig W., Patrono C., Pes-Kar B.M., Peskar B.A., Release of leukotriene C4 from human polymorphonuclear leukocytes as determined by radioimmu-noassay, FEBS Lett, 146, pp. 111-114, (1982)

[2]

Bobechko W.P., Hirsch C., Auto-immune response to nucleus pulposus in the rabbit, J Bone Joint Surg, 47B, pp. 574-580, (1965)

[3]

Bombardieri S., Cattani P., Ciabattoni G., Di Munno O., Pasero G., Patrono C., Pinca E., Pugliese F., The synovial pros-taglandin system in chronic inflammatory arthritis: Differential effects of steroidal and non-steroidal anti-inflammatory drugs, Br J Pharmacol, 73, pp. 893-901, (1981)

[4]

Brodie M.J., Hensby C.N., Parke A., Gordon D., Is prostacyclin the major pro-inflammatory prostanoid in joint fluid?, Life Sei, 27, pp. 603-608, (1980)

[5]

Corbett M., Dekel S., Puddle B., Dickson R.A., Francis M., The production of prostaglandins in response to experimenally induced osteomyelitis in rabbits, Prostaglandins Med, 2, pp. 403-412, (1979)

[6]

Egg D., Concentrations of prostaglandins D2, E2, F2a, 6-keto-PGFla and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis, Z Rheumatol, 43, pp. 89-96, (1984)

[7]

Famaey J.P., Phospholipases, eicosanoid production and inflammation, Clin Rheumatol, 1, pp. 84-94, (1982)

[8]

Franson R.C., Isolation and characterization of a phospho- lipase A2 from an inflammatory exsudate, J Lipid Res, 19, pp. 18-23, (1978)

[9]

Gertzbein S.D., Tile M., Gross A., Falk R., Autoimmunity in degenerative disc disease of the lumbar spine, Orthop Clin North Am, 6, pp. 67-73, (1975)

[10]

Greaves M.W., Camp R.D., Prostaglandins, leukotrienes phopholipase, platelet activating factor, and cytokines: An integrates approach to inflammation of human skin, Arch Dermatol Res, 280, pp. 33-41, (1988)

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