METHOTREXATE IN RHEUMATOID-ARTHRITIS - A 5-YEAR PROSPECTIVE MULTICENTER STUDY

被引:210
作者
WEINBLATT, ME
KAPLAN, H
GERMAIN, BF
BLOCK, S
SOLOMON, SD
MERRIMAN, RC
WOLFE, F
WALL, B
ANDERSON, L
GALL, E
TORRETTI, D
WEISSMAN, B
机构
[1] DENVER ARTHRIT CLIN,DENVER,CO
[2] UNIV S FLORIDA,COLL MED,TAMPA,FL
[3] ARTHRIT RHEUMAT & BACK DIS ASSOCIATES,CHERRY HILL,NJ
[4] BAYLOR UNIV,MED CTR,DALLAS,TX
[5] ARTHRITIS CTR,WICHITA,KS
[6] COLUMBUS MED CTR,COLUMBUS,OH
[7] RHEUMATOL ASSOCIATES,PORTLAND,ME
[8] ARIZONA HLTH SCI CTR,TUCSON,AZ
[9] GEISINGER MED CTR,DANVILLE,PA 17822
来源
ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 10期
关键词
D O I
10.1002/art.1780371013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To evaluate the efficacy and tolerability of oral methotrexate (MTX) in rheumatoid arthritis (RA) in a long-term prospective trial. Methods. One hundred twenty-three patients with RA who completed a 9-month multicenter randomized trial comparing MTX and auranofin enrolled in this 5-year prospective study of MTX. Results. Significant (P = 0.0001) improvement compared with baseline was noted in all clinical disease variables, functional status, and the Westergren erythrocyte sedimentation rate (ESR). ''Marked improvement'' occurred in 87 (71%) and 85 (69%) of the patients, respectively, in the joint pain/tenderness index and the joint swelling index at the last evaluable visit. Forty-four patients (36%) withdrew during the study. Eight (7%) withdrew due to lack of efficacy, and 8 (7%) due to adverse experiences, including 1 patient with cirrhosis, At 5 years, 64% of patients were still taking MTX and completed the study. Conclusion. This large prospective study of longterm MTX treatment demonstrates sustained clinical response and improvement in the Westergren ESR and functional assessment scores, with an acceptable toxicity profile.
引用
收藏
页码:1492 / 1498
页数:7
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