INFLUENCE OF FLUOROCARBON EMULSIONS ON PORPHYRIN-SENSITIZED OXIDATION OF HISTIDINE

被引：11

作者：

CHOWDHARY, RK

CUNDALL, RB

MORGAN, CG

机构：

[1] UNIV SALFORD,DEPT BIOL SCI,SALFORD M5 4WT,LANCS,ENGLAND

[2] MED RES COUNCIL RADIOBIOL UNIT,DIDCOT,OXON,ENGLAND

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 51卷 / 04期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb01730.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The influence of fluorocarbon emulsions on the efficiency of photosensitized oxidation of histidine in solution has been studied, using haematoporphyrin and dihaematoporphyrin derivatives as sensitisers. It is shown that the fluorocarbon emulsions at low concentrations efficiently disaggregate porphyrins, and thereby enhance photosensitised oxidation. The high solubility of oxygen in fluorocarbon emulsions maintains solution oxygen tension, optimising photooxidative damage. It is suggested that fluorocarbon emulsions might find a role in photodynamic therapy, both as carriers for sensitising dyes, and also to maintain tissue oxygenation in hypoxic regions of solid tumours. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：395 / 399

页数：5

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