SELECTIVE ELECTROCHEMICAL REMOVAL OF PROTECTING GROUPS IN NUCLEOTIDE SYNTHESIS

被引：20

作者：

ENGELS, J

机构：

[1] Fachbereich Chemie der Universität, Konstanz, D-7750

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1979年 / 18卷 / 02期

关键词：

D O I：

10.1002/anie.197901481

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Selective removal of an ester group from the completely protected nucleoside 3′‐phosphate 2 by electrochemical reduction solves a serious problem of nucleotide synthesis. Reaction (2) → (3) requires a potential of −0.5 V; (2) → (1) can be accomplished by acid hydrolysis. At −1.2 V the remaining ester groups are removed from 1. (Figure Presented.) Copyright © 1979 by Verlag Chemie, GmbH, Germany

引用

页码：148 / 149

页数：2

共 10 条

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