CHARACTERIZATION OF THE PROMOTER OF THE HUMAN GENE ENCODING THE HIGH-AFFINITY IGG RECEPTOR - TRANSCRIPTIONAL INDUCTION BY GAMMA-INTERFERON IS MEDIATED THROUGH COMMON DNA RESPONSE ELEMENTS

被引：174

作者：

PEARSE, RN ^{[1
]}

FEINMAN, R ^{[1
]}

RAVETCH, JV ^{[1
]}

机构：

[1] SLOAN KETTERING MEM CANC CTR,DIV MOLEC BIOL,DEWITT WALLACE RES LAB,1275 YORK AVE,NEW YORK,NY 10021

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 24期

关键词：

D O I：

10.1073/pnas.88.24.11305

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Expression of the high-affinity receptor for IgG (Fc(gamma)RI) is restricted to cells of myeloid lineage and is induced by y-interferon (IFN-gamma) but not by IFN-alpha/beta. The organization of the human Fc(gamma)RI gene has been determined and the DNA elements governing its cell type-restricted transcription and IFN-gamma induction are reported here. A 39-nucleotide sequence (IFN-gamma response region, or GRR) is defined that is both necessary and sufficient for IFN-gamma inducibility. Sequence analysis of the GRR reveals the presence of promoter elements initially defined for the major histocompatibility complex class II genes: i.e., X, H, and gamma-IRE sequences. Comparison of a number of genes whose expression is induced selectively by IFN-gamma indicates that the presence of these elements is a general feature of IFN-gamma-responsive genes. Our studies suggest that the combination of X, H, and gamma-IRE elements is a common motif in the pathway of transcriptional induction by this lymphokine.

引用

页码：11305 / 11309

页数：5

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