SYNTHESIS OF 5'-O-PHOSPHONOMETHYL-2',3'-DIDEHYDRO-2',3'-DIDEOXYURIDINE BY USE OF PARA-METHOXYBENZYL AS A N-3-PROTECTING GROUP

被引：21

作者：

VANAERSCHOT, A ^{[1
]}

JIE, L ^{[1
]}

HERDEWIJN, P ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN, REGA INST MED RES, PHARMACEUT CHEM LAB, MINDERBROEDERSSTR 10, B-3000 LOUVAIN, BELGIUM

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(00)85994-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Uridine derivatives are protected at N3-position with a p-methoxybenzyl group under Mitsunobu conditions. Selective removal is possible with ceric ammonium nitrate. The otherwise difficult to obtain 5'-O-phosphonomethyl d4U was prepared using this strategy.

引用

页码：1905 / 1908

页数：4

共 9 条

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