XENOGRAFTS - FUTURE-PROSPECTS FOR CLINICAL TRANSPLANTATION

被引：24

作者：

CAIRNS, TDH

TAUBE, DH

STEVENS, N

BINNS, R

WELSH, KI

机构：

[1] GUYS HOSP,DEPT IMMUNOGENET,LONDON SE1 9RT,ENGLAND

[2] ST MARYS HOSP,RENAL UNIT,LONDON,ENGLAND

[3] AFRC,CAMBRIDGE CB2 4AT,ENGLAND

来源：

IMMUNOLOGY LETTERS | 1991年 / 29卷 / 1-2期

关键词：

CLINICAL TRANSPLANTATION; XENOGRAFT;

D O I：

10.1016/0165-2478(91)90221-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This paper outlines the basic problems that still need to be overcome before xenografting becomes a reality. It presents evidence that if the first of these problems (preformed or natural antibody to pig) can be overcome then pig kidneys will: (a) not hyperacutely reject from a human; and (b) will not, under currently used immunosuppression, induce massive new primary or secondary responses. It also makes brief justification of the use of the pig as the donor of choice and outlines what essential animal work we feel necessary before an actual pig-to-human transplant is contemplated.

引用

页码：167 / 170

页数：4