DISCONTINUATION OF PHENYTOIN AND CARBAMAZEPINE IN PATIENTS RECEIVING FELBAMATE

被引：65

作者：

WAGNER, ML

GRAVES, NM

MARIENAU, K

HOLMES, GB

REMMEL, RP

LEPPIK, IE

机构：

[1] UNIV MINNESOTA,COLL PHARM,DEPT PHARM PRACTICE,HLTH SCI UNIT F,308 HARVARD ST,MINNEAPOLIS,MN 55455

[2] UNIV MINNESOTA,DEPT NEUROL,MINNEAPOLIS,MN 55455

[3] MINCEP EPILEPSY CARE PA,MINNEAPOLIS,MN

[4] PHARMACO DYNAM RES,AUSTIN,TX

来源：

EPILEPSIA | 1991年 / 32卷 / 03期

关键词：

ANTICONVULSANTS; FELBAMATE; EPILEPSY; DRUG INTERACTIONS; PHENYTOIN; CARBAMAZEPINE;

D O I：

10.1111/j.1528-1157.1991.tb04669.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Five patients participated in a controlled discontinuation of phenytoin (PHT) and carbamazepine (CBZ) after a study in which all subjects had felbamate (FBM) added to both PHT and CBZ. Four subjects (three women and 1 man aged 23-36 years) completed the protocol. Mean total seizure frequency per day with PHT and CBZ was 1.33 +/- 0.93 (mean +/- SEM), decreasing to 0.87 +/- 0.71 with addition of FBM, and 0.82 +/- 0.78 after discontinuation of PHT. Only one subject tolerated discontinuation of CBZ; the other three had dosage reductions of 33, 54, and 63%. Toxicity attributable to FBM was not observed, and patients often described less severe seizures. Results from four refractory patients indicated that FBM was able to replace PHT and reduce the need for CBZ. In addition, as PHT dosages were reduced, FBM clearance decreased 21%. As the CBZ dosages were reduced, FBM clearance decreased an additional 16.5%.

引用

页码：398 / 406

页数：9

共 14 条

[1]

ADUSUMALLI VS, 1983, BC831 WALL LAB REP

[2] FELBAMATE INCREASES PHENYTOIN BUT DECREASES CARBAMAZEPINE CONCENTRATIONS [J].