ANTINEOPLASTIC DRUG-RESISTANCE AND DNA-REPAIR

被引:19
作者
BURT, RK
POIRIER, MC
LINK, CJ
BOHR, VA
机构
[1] NCI,MOLEC PHARMACOL LAB,BLDG 37,ROOM 5C25,BETHESDA,MD 20892
[2] NCI,CELLULAR CARCINOGENESIS & TUMOR PROMOT LAB,BETHESDA,MD 20892
[3] NCI,CLIN ONCOL PROGRAM,BETHESDA,MD 20892
关键词
D O I
10.1093/oxfordjournals.annonc.a057949
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Important aspects of the DNA repair mechanisms in mammalian, and especially human, cells are reviewed. The DNA repair processes are essential in the maintenance of the integrity of the DNA and in the defense against cancer. It has recently been discovered that the DNA repair efficiency differs in different regions of the genome and that active genes are preferentially repaired. There is mounting evidence that DNA repair processes play a role in the development of drug resistance by tumor cells. We will discuss such data as well as further approaches to clarify the relationship between DNA repair and antineoplastic drug resistance. Specifically, there is an increasing need to investigate the intragenomic heterogeneity of DNA repair and correlate the repair efficiency in specific genes to aspects of drug resistance. We also discuss the therapeutic potential of inhibiting the DNA repair processes and thereby possibly overcoming drug resistance.
引用
收藏
页码:325 / 334
页数:10
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