PROTEIN-KINASE-C ACTIVITY AND CONTRACTILE RESPONSIVENESS IN SENESCENT BLOOD-VESSELS

被引：6

作者：

JOHNSON, MD

WANG, HY

FRIEDMAN, E

机构：

[1] MED COLL PENN, DEPT PHARMACOL, PHILADELPHIA, PA 19129 USA

[2] MED COLL PENN, DEPT PSYCHIAT, PHILADELPHIA, PA 19129 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1990年 / 189卷 / 06期

关键词：

PROTEIN KINASE-C; BLOOD VESSEL; CONTRACTION; AGING; PHORBOL ESTER; (FISCHER-344 RAT);

D O I：

10.1016/0922-4106(90)90038-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To examine Ca2+-signaling receptor function in the aging vasculature, the status of the diacylglycerol/protein kinase C (DAG/PKC) arm of the signal transduction pathway was assessed. Contractile responsiveness to the PKC activator, phorbol 12-myristate 13-acetate (PMA), is substantially reduced in aortae from 24-month-old Fischer 344 rats compared to 6-month-old rats. PKC activity is reduced in all senescent vessels yet studied including aorta, renal artery, iliac artery and vena cava. This may account for the reduced contractile responsiveness. Additionally, PMA-stimulated PKC translocation is substantially reduced in senescent aorta and this may also contribute to reduced contraction.

引用

页码：405 / 410

页数：6

共 26 条

[1] CALCIUM-MOBILIZING RECEPTORS, POLYPHOSPHOINOSITIDES, GENERATION OF 2ND MESSENGERS AND CONTRACTION IN THE MAMMALIAN IRIS SMOOTH-MUSCLE - HISTORICAL PERSPECTIVES AND CURRENT STATUS [J].