THE SOS (SON OF SEVENLESS) PROTEIN

被引：39

作者：

BARSAGI, D

机构：

[1] Dafna Bar-Sagi is at Cold Spring Harbor Laboratory, Cold Spring Harbor

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 04期

关键词：

D O I：

10.1016/1043-2760(94)90014-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Drosophila Son of sevenless (Sos) gene functions in the signaling pathway initiated by the Sevenless receptor tyrosine kinase. It encodes the Drosophila homologue of CDC25, an activator of Ras in the yeast Saccharomyces cerevisiae. Two widely expressed mammalian homologues of Sos (mSos) have now been identified and characterized They encode for 150-kD proteins that ave Ras-specific guanine nucleotide exchange factors. Generic and biochemical studies indicate that Sos proteins bind directly to the SH2- and SH3-domain-containing adaptor protein GRB2/Drk. This interaction defines a pathway by which receptor tyrosine kinases can communicate with Ras.

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页码：165 / 169

页数：5

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