GENERALIZED ARTERIAL FIBROMUSCULAR DYSPLASIA AND MYOCARDIAL INFARCTION IN FAMILIAL SUPRAVALVULAR AORTIC STENOSIS SYNDROME

Postmortem examination of two infant sisters with findings of the supravalvular aortic stenosis syndrome revealed generalized fibromuscular dysplasia of the major systemic arteries and of the entire pulmonary trunk, without any supravalvular narrowing of the aorta. Many infarcts of the myocardium, both old and recent, were found in both patients. The vascular lesions were strikingly similar to those found in the rubella syndrome and in fibromuscular dysplasia of the renal arteries. © 1969 The C. V. Mosby Company.