NERVOUS SYSTEM-SPECIFIC S-100 ANTIGEN IN CEREBROSPINAL-FLUID OF MULTIPLE-SCLEROSIS PATIENTS

被引：77

作者：

MICHETTI, F ^{[1
]}

MASSARO, A ^{[1
]}

MURAZIO, M ^{[1
]}

机构：

[1] UNIV CATTOLICA SACRO CUORE,DEPT NEUROL,ROME,ITALY

来源：

NEUROSCIENCE LETTERS | 1979年 / 11卷 / 02期

关键词：

D O I：

10.1016/0304-3940(79)90122-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The nervous system-specific S-100 antigen has been found in cerebrospinal fluid (CSF) of 13 out of 18 patients with multiple sclerosis (MS), whereas it was undetectable in either of the 11 control patients with minor psychic disturbances or with neurological disorders not usually associated with apparent parenchymal lesion. The levels of the antigen appeared to be higher in CSF of patients in the acute phase of the disease. Though the small number of cases hampers final statements, the S-100 in CSF might serve as a possible index of active cell injury in the central nervous system underlying the pathogenesis of MS. © 1979.

引用

页码：171 / 175

页数：5

共 18 条

[1] PATHOLOGY OF MULTIPLE-SCLEROSIS - PROGRESSION OF LESION [J].