REGULATORY INFLUENCES ON THE RESPONSE OF RABBIT T-CELLS TO CONCANAVALIN-A AND PHYTOHEMAGGLUTININ

被引：10

作者：

ALCALA, ARR ^{[1
]}

CHOU, CT ^{[1
]}

CINADER, B ^{[1
]}

DUBISKI, S ^{[1
]}

FILOSA, MF ^{[1
]}

机构：

[1] UNIV TORONTO,INST IMMUNOL,TORONTO M5S 1A8,ONTARIO,CANADA

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 04期

关键词：

D O I：

10.1111/j.1365-3083.1979.tb03169.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The proliferative response, induced in rabbit spleen cell by concanavalin A (Con A) and phyto‐haemagglutinin (PHA), is abolished when T cells are killed with antibody againsi rabbit thymus lymphocyte antigen (RTLA) in the presence of complement. The response was examined witb puritied spleen T cells, to whieh various helper cell factions were added; it could he shown that B cells help the responding T cells, The helper effect in ihe response to PHA is abolished imd ihe response to Con A is reduced by any manoeuvre which destroys or removes B cells. Help by B cells is given when helper cells have lost proliferative capacity as a consequence of mitomycin‐C treatment. Spleen cells adhering to the walls of culture tubes help suspended T spleen cells in their response to Con A. This help could be abolished by complement mediated coll kill with antibody to rabbit bursal equivalent lymphocyte antigen (RABELA). On the other hand, the helper effect in Con A response was increased when T cells were removed. Thus the response of T cells to Con A is regulated by helper B cells and suppressor T cells. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：315 / 324

页数：10

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