RECOMBINANT-HUMAN-ERYTHROPOIETIN FOR A JEHOVAH WITNESS WITH ANEMIA OF THERMAL-INJURY

被引：24

作者：

BOSHKOV, LK

TREDGET, EE

JANOWSKAWIECZOREK, A

机构：

[1] UNIV ALBERTA HOSP,DEPT MED,EDMONTON T6G 2B7,ALBERTA,CANADA

[2] UNIV ALBERTA HOSP,DEPT SURG,EDMONTON T6G 2B7,ALBERTA,CANADA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1991年 / 37卷 / 01期

关键词：

RECOMBINANT HUMAN ERYTHROPOIETIN (RH-EP); BURNS; ANEMIA;

D O I：

10.1002/ajh.2830370113

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the use of recombinant human erythropoietin (rh-Ep) as an alternative to transfusion therapy in a burn victim who was a Jehovah's Witness and refused blood transfusion. Despite endogenous elevated erythropoietin levels, the patient was reticulocytopenic and administration of rh-Ep was accompanied by a 10-fold increase in reticulocyte response and a rise in hemoglobin from 7.4 to 10.4 g/dl over a 12-day period. We suggest that the exogenously administered erythropoietin overcame a clinically inadequate endogenous erythropoietin response.

引用

页码：53 / 54

页数：2

共 6 条

[1]

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[2]

CLIBON U, 1990, EXP HEMATOL, V18, P438

[3]

JOHNSON CS, 1990, EXP HEMATOL, V18, P109

[4] INHIBITION BY INTERLEUKIN-1 OF THE ACTION OF ERYTHROPOIETIN ON ERYTHROID PRECURSORS AND ITS POSSIBLE ROLE IN THE PATHOGENESIS OF HYPOPLASTIC ANEMIAS [J].