NITRIC-OXIDE SYNTHASE IN VIP-CONTAINING VASODILATOR NERVE-FIBERS IN THE GUINEA-PIG

被引：150

作者：

KUMMER, W ^{[1
]}

FISCHER, A ^{[1
]}

MUNDEL, P ^{[1
]}

MAYER, B ^{[1
]}

HOBA, B ^{[1
]}

PHILIPPIN, B ^{[1
]}

PREISSLER, U ^{[1
]}

机构：

[1] GRAZ UNIV,INST PHARMACOL & TOXICOL,A-8010 GRAZ,AUSTRIA

来源：

NEUROREPORT | 1992年 / 3卷 / 07期

关键词：

NITRIX OXIDE; NITRIC OXIDE SYNTHASE; NITRERGIC NERVE FIBERS; VASCULAR INNERVATION; CHOLINERGIC INNERVATION; VASODILATION;

D O I：

10.1097/00001756-199207000-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE investigated the possibility of nitric oxide (NO), a powerful vasodilator agent, being synthesized by perivascular nerve fibres. Immunoreactivity and catalytic activity of the NO synthesizing enzyme, NO synthase (NOS), were demonstrated in perivascular nerve fibres of blood vessels receiving autonomic vasodilator innervation, but not of those innervated exclusively by vasoconstrictor nerve fibres. Double-labelling techniques allowed identification of NOS-containing nerve fibres as belonging to the vasoactive intestinal peptide (VIP)/acetylcholine-containing class whereas noradrenergic and substance P-containing perivascular fibres were devoid of NOS. We suggest that, in addition to its endothelial source, NO is a neuronal co-mediator of VIP/cholinergic vasodilation.

引用

页码：653 / 655

页数：3

共 16 条

[1] LOCALIZATION OF NITRIC-OXIDE SYNTHASE INDICATING A NEURAL ROLE FOR NITRIC-OXIDE [J].