PENETRATION OF FIMBRIATE ENTERIC BACTERIA THROUGH BASEMENT-MEMBRANES - A HYPOTHESIS

被引:37
作者
KORHONEN, TK
VIRKOLA, R
LAHTEENMAKI, K
BJORKMAN, Y
KUKKONEN, M
RAUNIO, T
TARKKANEN, AM
WESTERLUND, B
机构
关键词
BASEMENT MEMBRANE; ESCHERICHIA-COLI; FIMBRIAE; LAMININ; PLASMIN;
D O I
10.1111/j.1574-6968.1992.tb05720.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A mechanism for penetration of basement membranes by Escherichia coli is presented. The mechanism is based on the ability of the S fimbriae of meningitis-associated E. coli to bind to vascular endothelium and choroid plexuses in brain and to basement membranes. On the other hand, the S and the type 1 fimbriae of E. coli immobilize plasminogen and tissue-type plasminogen activator; this process generates proteolytic plasmin activity on the surface of fimbriate cells. Our hypothesis is that bacterium-bound plasmin activity, directed to basement membranes through fimbrial binding, promotes bacterial penetration through basement membranes.
引用
收藏
页码:307 / 312
页数:6
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